Zika virus infection of HBMECs and in vitro BBB model enhanced expression of type I and III IFNs and induced a significant increase in the release of cytokines [interleukin-1β (IL-1β), interleukin-8 (IL-8), IL-6, and TNF-α], chemokines [C-C motif ligand-2 (CCL2/MCP-1) and CCL5], and CAMs [vascular cell adhesion molecule 1 (VCAM1) and intercellular adhesion molecule 1 (ICAM1)]. This evidence concerns the gene IL6 and Zika virus infectious disease.