The process is mediated by the upregulation of C-X-C motif chemokine 12 (CXCL12) in monocyte during ZIKV infection, a key regulator of lymphocytes shifts across BBB into CNS parenchyma as it interacts with C-X-C chemokine receptor type 4 (CXCR4). Here, CXCR4 is linked to Zika virus infectious disease.