1. Improved insulin resistance due to inhibition of tyrosine phosphatase and improved insulin sensitivity, restored ciclicity, decreased IGF-1, increased IGFBP-1 and down-regulated T in PCOS rats 2. Hepatoprotective, antioxidant, anti-obesity, antihyperlipidemic and antidiabetic activities. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.