1. “Reduced the ovarian volume and number of follicles and improved the menstrual cycles but did not alter the body weight, blood sugar or hirsutism” 2. “Positive effect on PCOS, due to the reduction in T, E2, LH and insulin levels which contributed to follicular maturation, and the anti-inflammatory actions to the reduction in ovarian volume”. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.