1. Reduced both left and right ovarian volume and number of ovarian cysts but no significant adverse effects in serum ALT, BUN and CK 2. Increased LH and FSH levels and a small decrease in LH: FSH ratio 3. Effective in alleviating the symptoms of PCOS and demonstrated broad-spectrum safety and efficacy. The gene discussed is PLOD1; the disease is Ovarian cyst.