Histology identified a necrotic core and a highly perfused rim region with high cancer cell density (Fig. 3G, H) and confirmed the OA appearance showing high vascular density around the tumor rim (Fig. 3E, F); one such area is highlighted with an arrow on Fig. 3E. Case 3 (Fig. 3I, J) is also shown to better illustrate the carcinoma pattern seen in Case 2 and depicts a HER2-positive NST tumor. Here, ERBB2 is linked to cancer.