In two pilot breast cancer studies, multi-spectral optoacoustic tomography (MSOT) revealed increased vascularization in the periphery of tumors and a concomitant reduction in the tumor core, as well as heterogeneous total blood volume and irregular deoxy-hemoglobin (Hb) and oxy-hemoglobin (HbO2) signal patterns in the tumor area [4], [69]. Here, GSTM1 is linked to neoplasm.