Moreover, Li et al. found that MFG-E8 had a protective role in relieving lipid accumulation and inflammatory response through binding to apoptosis signal-regulating kinase 1 (ASK1) and inhibiting its dimerization and phosphorylation in the pathogenesis of the non-alcoholic fatty liver disease (25). The gene discussed is MAP3K5; the disease is metabolic dysfunction-associated steatotic liver disease.