TPE might remove critically important neutralizing antibodies against SARS-CoV-2 regardless of the inflammatory state of the patient, as confirmed by a recent case of life-threatening COVID-19–associated sepsis, with anti SARS-CoV-2-specific IgG and IgA antibodies found in the plasma bag following TPE and reduction by one log step of patient's circulating antibodies (37). This evidence concerns the gene CD79A and COVID-19.