TPE might remove critically important neutralizing antibodies against SARS-CoV-2 regardless of the inflammatory state of the patient, as confirmed by a recent case of life-threatening COVID-19–associated sepsis, with anti SARS-CoV-2-specific IgG and IgA antibodies found in the plasma bag following TPE and reduction by one log step of patient's circulating antibodies (37). The gene discussed is CD79A; the disease is Sepsis.