AHR and Autoimmunity: In addition, the induction of AhR signaling enhances de secretion of the antiinflammatory cytokines such as IL-22 and IL-10 while reducing the production of the proinflammatory cytokines such as tumor necrosis factor-alpha, IL-1, IL-6, and IL-12 that are also the desirable effects against autoimmunity (34, 35, 73).