LP-HFY05 and dipyridamole could down-regulate NF-κB p65, IL-6, TNF-α, and IFN-γ expression in renal tissues of mice with thrombosis, and the effects of LP-HFY05-H and dipyridamole were similar, and the effects of both were significantly better (P < 0.05) than those of LP-HFY05-L. The gene discussed is NFKB1; the disease is Venous thrombosis.