The incidence of solid cancer in RA patients treated with tumor necrosis factor α inhibitors (TNFi) and conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs) was 0.81 and 1.17 per 100 person-years, respectively, and no difference was found between the two groups after adjusting for baseline characteristics (hazard ratio [HR] = 0.83, 95%CI 0.64–1.07) (Mercer et al., 2015). This evidence concerns the gene TNF and rheumatoid arthritis.