In both HF animal models and HF patients, the activities of JNK and p38MAPK in the failed myocardium are significantly higher than those in the healthy heart; also, the activities of JNK and p38MAPK in severe HF patients are also significantly higher than those in mild HF patients (Cook et al., 1999; Arabacilar and Marber, 2015). The gene discussed is MAPK8; the disease is hydrops fetalis.