Upon treatment with anti-PD-1 and anti-PD-L1 therapies, Vilain et al., 2017 showed an infiltration of PD-1+ T-cells in tumor, as well as upregulation of tumoral PD-L1 and macrophage PD-L1 of responders (Vilain et al., 2017). The gene discussed is CD274; the disease is neoplasm.