Emerging evidence indicates that PINK1/Parkin-mediated mitophagy plays an essential role in the pathogenesis of various kinds of aging-associated pulmonary disorders, such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) (Tsubouchi et al., 2018; Siekacz et al., 2021). The gene discussed is PRKN; the disease is chronic obstructive pulmonary disease.