HGF and lung adenocarcinoma: In lung adenocarcinoma cells, siRNA screen identified USP30 as one of the strongest hits involved in the hepatocyte growth factor (HGF)-induced cell scattering response (Birchmeier et al., 2003; Gentile et al., 2008), implying a role of USP30 in cancer cell metastatic (Buus et al., 2009) (Table 1).