PINK1/Parkin-mediated mitophagy has an important role in regulating cell fates, including cellular senescence, programmed cell death, and myofibroblast differentiation during the pathogenesis of COPD and IPF (Araya et al., 2013a; Kuwano et al., 2016). This evidence concerns the gene PRKN and idiopathic pulmonary fibrosis.