Pnpla3 (patatin-like phospholipase domain-containing 3) codes for a protein that has been linked to the progression of fatty liver disease, including nonalcoholic steatohepatitis, and lies downstream of SREBP-1c, an important regulator of fatty acid synthesis (Bruschi et al., 2017; Basu Ray, 2019). The gene discussed is SREBF1; the disease is metabolic dysfunction-associated steatohepatitis.