Recently, the role of platelets in driving chronic intestinal inflammation and fibrosis has been elegantly demonstrated by Sacco et al. (2019) by generating a mouse with the specific deletion of cyclooxygenase (COX)-1 in megakaryocytes/platelets (platelet COX-1 cKO mouse) treated with dextran sodium sulfate (DSS) to induced colitis. The gene discussed is PTGS1; the disease is colitis.