By stimulating the sirtuin 1 (SIRT1)/peroxisome proliferator-activated receptor alpha (PPARα)/Fibroblast growth factor 21 (FGF21) pathway, APS could alleviate lipid metabolism disorder, notably, by increasing hepatic glycolipid metabolism, reducing inflammation, and lipid droplet deposition (Gu et al., 2015). The gene discussed is SIRT1; the disease is Disorder of lipid metabolism.