Surprisingly, there is a pharmacological investigation revealed that oxymatrine markedly blocked the migration and invasion of CRC RKO cells via inhibiting NF-κB p65 activation, and then regulated the EMT-associated genes, such as E-cadherin, N-cadherin, and Snail expressions to reverse the EMT process (Liang and Huang, 2016). Here, CDH2 is linked to colorectal carcinoma.