CXCR4 and neoplasm: Further, it was also reported that curcumin (Zhang et al., 2016) strongly hindered tumor EMT through downregulating Nkd2-Wnt-CXCR4 signaling, then mediation of EMT-associated markers E-cadherin and vimentin expressions, resulting in a reduction of invasive and metastatic abilities in SW620 CRC cells.