In summary, these accumulating pharmacological investigations demonstrated that TGF-β1/Smad plays a crucial role in the regulation of metastatic CRC, and these above-mentioned Chinese herbal compounds and formulas exerted strong inhibitory activities on the invasion and metastasis potential of CRC via down-regulating EMT-related TGF-β/Smad signal pathway. Here, TGFB1 is linked to colorectal carcinoma.