PRICKLE2 and colorectal carcinoma: Notably, it has been proven that curcumin treatment was effective in inhibiting the EMT process in SW620 and HT29 CRC cells by up-regulation of miR-200c and down-regulation of EPM5, suggesting that curcumin might be able to prevent or restrain tumor metastasis in CRC progression (Wang H. et al., 2020).