Furtherly, the RCWE, ALWE, ALEE, ginsenoside Rg3R, and ginseng ethanol extract also exhibit strong inhibitory efficacy on metastasis and invasion potential by restraining MMP-2 and MMP-9 activities, which is effectively conducive to decrease degradation of ECM, thereby inhibiting cell invasion and migration in CRC progression. Here, MMP9 is linked to colorectal carcinoma.