It has been reported that ginsenoside Rg3 could effectively inhibit invasion and metastases of HCT15 cells and SW48 cells through restraining the Notch-Hes1-EMT signal pathway activation, specifically increasing E-cadherin, while decreasing EMT-related markers vimentin, Snail, Notch ICD, and Hes1 expressions, as well as decreasing the tumor metastasis nodules in the liver of metastasis model mice (Li X. et al., 2021). This evidence concerns the gene HES1 and neoplasm.