Of note, SYD has been confirmed to be effective in reversing the EMT program by inhibiting NF-κB p65 activation, thus presented as up-regulation of E-cadherin and down-regulation of N-cadherin, vimentin, fibronectin, and EMT-TFs Snail expressions in the azoxymethane and dextran sodium sulfate-induced colitis-associated CRC model mice and in SW480 and HCT116 cells (Lin X. et al., 2014). Here, CDH2 is linked to colorectal carcinoma.