VIM and neoplasm: It has been reported that ginsenoside Rg3 could effectively inhibit invasion and metastases of HCT15 cells and SW48 cells through restraining the Notch-Hes1-EMT signal pathway activation, specifically increasing E-cadherin, while decreasing EMT-related markers vimentin, Snail, Notch ICD, and Hes1 expressions, as well as decreasing the tumor metastasis nodules in the liver of metastasis model mice (Li X. et al., 2021).