Notably, ginsenoside Rb2 was found to decrease colony-forming ability, metastasis, and invasion in vitro, and the mesenchymal indicators containing Snail, twist, fibronectin, vimentin, and MMP-2 were markedly down-regulated in the presence of ginsenoside Rb2, whereas E-cadherin was up-regulated in both HT29 and SW620 CRC cell lines (Phi et al., 2018). Here, TWIST1 is linked to colorectal carcinoma.