Interestingly, we can observe that Chinese herbal prescription including PZH, SBS, JPJD, and natural herb compounds containing resveratrol, berberine, ginsenoside Rb2, oxymatrine, quercetin, and SBPW3 are shown to be obviously effective in combating EMT-induced metastasis of CRC cells via inhibiting TGF-β1/Smads signaling in vitro and in vivo models experiment. Here, TGFB1 is linked to colorectal carcinoma.