Interestingly, it was displayed that treatment with resveratrol was also conducive to reducing the tumor invasion and metastasis capabilities in AKT1-knockdown SW480 and SW620 cells, and remarkably up-regulated E-cadherin expression and down-regulated p-AKT1, p-GSK-3β, Snail, and N-cadherin expressions in the CRC cells and in a lung metastasis mice model inoculated with SW480 cells. The gene discussed is CDH1; the disease is neoplasm.