TGFB1 and neoplasm: Furthermore, SBPW3 is a homogeneous polysaccharide separated from the plant of Scutellaria barbata D.Don [Lamiaceae], which significantly repressed TGF-β1-induced metastasis and invasion of CRC HT-29 cells through reversing the EMT program via mediating EMT-related phenotypes and blocking the Smad2/3 signaling pathway, as well as SBPW3 significantly suppressed the metastatic dissemination of the primary tumor to the liver of mice of CRC metastasis model (Li et al., 2019a).