Then the trimeric Smad heterocomplexes translocate into the nucleus and activate the mesenchymal phenotype genes involve master regulators, including Snail, Slug, Twist, and ZEB1/2 (Lamouille et al., 2014), whereas repressing the epithelial phenotype, thereby acquired the EMT phenotype (Avila-Carrasco et al., 2019), eventually facilitating tumor cell invasion and metastasis in CRC progression. The gene discussed is ZEB1; the disease is neoplasm.