Furthermore, SBPW3 is a homogeneous polysaccharide separated from the plant of Scutellaria barbata D.Don [Lamiaceae], which significantly repressed TGF-β1-induced metastasis and invasion of CRC HT-29 cells through reversing the EMT program via mediating EMT-related phenotypes and blocking the Smad2/3 signaling pathway, as well as SBPW3 significantly suppressed the metastatic dissemination of the primary tumor to the liver of mice of CRC metastasis model (Li et al., 2019a). The gene discussed is SMAD2; the disease is neoplasm.