Upregulation of miR-223 was associated with the downregulation of RASA in CRC tissues, and C/EBP-β-activated miR-223 improved colorectal cancer cell growth and stimulated tumorigenesis by targeting RASA in CRC (Sun et al., 2013; Sun et al., 2015). The gene discussed is RASA1; the disease is colorectal carcinoma.