GADD45A and neoplasm: More recent studies indicated GADD45A could even act as a tumor suppressive gene by facilitating apoptosis, maintaining cell-to-cell adhesion, inhibiting angiogenesis, modulating drug resistance, suppressing metastasis, promoting DNA repair, and stabilizing genomics (Yang et al., 2013; Bartoszewski et al., 2020; Runtian Wang et al., 2021).