A study by Pollock et al. (2016) investigated the effect of injecting MSCs engineered by lentiviral transduction to overexpress Brain-derived neurotrophic factor (BDNF) into a mouse model of HD, as BDNF is known to be a lead candidate for HD treatment (Zuccato and Cattaneo 2007). This evidence concerns the gene BDNF and Huntington disease.