The twitcher mouse model is an authentic model of human Krabbe disease that developed through spontaneous mutation of the gene encoding galactosylceramidase at the Jackson Laboratory in 1976 (Kobayashi et al., 1980) this model presents biochemical and histopathological symptoms that are similar to the human form of Krabbe disease such as loss of oligodendrocytes or demyelination (Suzuki and Suzuki 1995; Ripoll et al., 2011). This evidence concerns the gene GALC and Krabbe disease.