In animal experiments, PPARγ agonists were shown to improve the effects of kidney injury by preventing mesangial expansion, glomerulosclerosis, tubulointerstitial inflammation and fibrosis, and tubular dilation and atrophy, with partial improvements observed after the downregulation of renal disintegrin and metalloprotease-17 as well as angiotensin-converting enzyme-2 shedding (Ohga et al., 2007; Bilan et al., 2011; Chodavarapu et al., 2013). Here, PPARG is linked to glomerulosclerosis.