PPARA and acute kidney injury: PPARα ligands attenuate cisplatin-induced AKI by preventing the inhibition of FAO (Li et al., 2004a), reducing apoptosis and necrosis in proximal tubule cells through a decrease in endonuclease G activity (Li et al., 2004b), and limiting inflammatory processes by blocking NF-κB activity (Li et al., 2005; Baud and Letavernier, 2007).