NQO1 and Cowden disease: The main findings are as follows: (1) RUS ameliorates CD-like colitis by upregulating the expression of proteins associated with the Nrf2/NQO1 pathway; (2) RUS suppresses inflammatory responses in intestinal epithelial cells; and (3) RUS inhibits apoptosis of intestinal epithelial cells to protect the integrity of the intestinal barrier.