During the period of osteogenic differentiation, sh-TCONS_00072128 group, which simulated osteoporosis, inhibited the inflammation factors such as NLRP3and NF-κB, indicating that the inflammation inhibition may have a positive effect; However, the decreased expression of Caspase8 inhibited cell differentiation, even though cell growth was not significantly affected, the differentiation capacity may become lower. Here, NFKB1 is linked to osteoporosis.