Using a random effect model, a further subanalysis revealed that PON-1 arylesterase activity remained significant lower in patients with CAD both in Asian (SMD: -0.558, 95% CI: -0.917 to -0.200, p = 0.002, I2: 91%) and European (SMD: -0.298, 95% CI: -0.497 to -0.015, p = 0.003, I2 = 90%) populations (forest plot shown in Online Resource 4). Here, PON1 is linked to coronary artery disorder.