Furthermore, the KEGG analysis showed that the RASGs between LG samples and HG samples were mainly enriched in “cell cycle, apoptosis, spliceosome, apoptosis–multiple species, neurotrophin signaling pathway, shigellosis, insulin resistance, insulin signaling pathway, pathogenic Escherichia coli infection, and p53 signaling pathway” (Supplementary Figure S2B). Here, BDNF is linked to escherichia coli infection.