The KEGG analysis indicated that RBP-regulated ASEs between two doses of glucose-treated HRECs were mainly enriched in “cell cycle, spliceosome, pathogenic Escherichia coli infection, p53 signaling pathway, insulin signaling pathway, mTOR signaling pathway, bacterial invasion of epithelial cells, ubiquitin-mediated proteolysis, insulin resistance, and apoptosis–multiple species” (Supplementary Figure S3A). This evidence concerns the gene INS and escherichia coli infection.