ATAD2 and neoplasm: During tumorigenesis, ATAD2 is highly expressed and disturbes the RB-E2F pathway, which contributes to tumor development.9 ATAD2 has been reported to function as a transcriptional co-regulator for several oncogenic transcriptional factors such as estrogen receptor or the androgen receptor and the transcription factors E2F and MYC (Master Regulator of Cell Cycle Entry and Proliferative Metabolism).9 It has been suggested that ATAD2 might link ocogenic and proliferation pathways and that this drives to the development of aggressive tumors.