FGF21 decreases TC levels through suppression of hepatic sterol regulatory element‐binding protein 2 (Srebp‐2) and augmentation of cholesterol efflux, possibly by increasing ABCG5/8 expression in ApoE and FGF21 double KO mice,16 and prevents increases in blood glucose levels in a type 1 diabetes mouse model.31 The gene discussed is APOE; the disease is type 1 diabetes mellitus.