DDIT3 and colorectal carcinoma: Compared to mutant KRAS CRC cells (n = 4), WT KRAS CRC cells (n = 4) showed higher IC50, reduced apoptosis, and lower induction of stress (p-eIF2α, CHOP, GADD45B), DR5, and cleaved caspase-3 (Fig. 4a-b, Fig. S4a-b).