Consistently, Kohiand colleagues reported that hyaluronan levels in the culture supernatant of PDAC cells are significantly increased in response to treatment with a DNMT1 inhibitor.32 Thus, PAS1 knockdown may promote the degradation of hyaluronan by upregulating PH20 to facilitate cancer cell migration, which provides a novel mechanism through which PAS1 blocks cancer metastasis. The gene discussed is SPAM1; the disease is cancer.