Large-scale brain abnormalities are linked to both morphological and functional organization in ASD, according to previous clinical findings.14,15 Autism spectrum disorder and CDD may partially involve an autoimmune pathogenesis.3 It has a pathological role in neutrophillear autoimmunity.16 Progranulin, a neurotrophic factor expressed primarily in neurons and microglia, suppresses neutrophil activation and inflammatory activity, making it a significant anti-inflammatory suppressor.17 Here, GRN is linked to craniodiaphyseal dysplasia.