In pancreatic cancer, over-expressed ubiquitin carboxyl-terminal hydrolase L3 (UCHL3) was reported to stabilize Forkhead box protein M1 (FOXM1), which activates the transcription of LDHA, and promotes aerobic glycolysis of pancreatic cancer through the UCHL3-FOXM1-LDHA axis [36]. Here, UCHL3 is linked to familial pancreatic carcinoma.