Improvement in triglyceride and free fatty acid by reduction of chylomicron synthesis in enterocytes [9], downregulation of SREBP-1c [19], or autophagy induction through AMPK activation and TFEB nuclear translocation [11] has been suggested as mechanisms by which ezetimibe contributes to improved hepatic steatosis and inflammation. The gene discussed is TFEB; the disease is fatty liver disease.