Additionally, LPA and amitriptyline have been shown to reduce basal P-gp activity through LPAR1 signaling without affecting the activity of MRP2 (multidrug resistance-associated protein 2) or BCRP (breast cancer resistance protein) in both rat brain capillaries and a rat model of amyotrophic lateral sclerosis [152]. The gene discussed is ABCG2; the disease is amyotrophic lateral sclerosis.