GATD3 and dilated cardiomyopathy: Concordantly, we observed augmented AGE immunoreactivity of mitochondrial ribosomal 16S and 12S RNA species and enhanced protein 1,2-dicarbonyl and AGE immunoreactivity in the heart left ventricle of aged Gatd3a−/− mice, which can potentially result in breakdown of their electron dense cristae structure, a phenotype indicative of dilated cardiomyopathy [50].