Accordingly, flow cytometry analysis of Th2 lymphocytes at baseline and after 6 months of chemotherapy can be highly informative and may be necessary to clarify whether Th2 lymphocytes are implicated in the elevation of IL-4 and IgE production in ALL patients and consequently, post-chemotherapy allergic manifestations in the atopy ( +) group. This evidence concerns the gene IGHE and acute lymphoblastic leukemia.