Among members of the GPCR family, gonadotropin-releasing hormone receptor (GnRH) has been reported to be overexpressed in various tumor cells such as melanoma, prostate and endometrial cancer, leiomyoma, breast cancer, choriocarcinoma, epithelial ovarian tumor, and stromal ovarian tumor [28]. The gene discussed is GNRH1; the disease is leiomyoma.