APOE and age-related macular degeneration: APOE is associated with AMD,[48] where the ApoE protein acts as a ligand for the low‐density lipoprotein receptor (LDL‐R) and is also secreted apically and basolaterally by RPE cells.[49] Furthermore, ApoE is a component of sub‐retinal debris.[50] We therefore probed for ApoE expression in the outer retinae of HFD mice, which showed no changes compared to mice fed a chow diet.