The performance of p-tau217 in plasma is also promising, having a high accuracy in the diagnosis and differential diagnosis of AD by Aβ-PET or tau-PET as the outcome compared with plasma p-tau181 (AUC, 0.87 or 0.93 vs 0.76 or 0.83, P <0.001), and there is no significant difference between plasma p-tau217 and CSF p-tau217 using tau-PET as the outcome (AUC, 0.93 vs 0.96, P = 0.22) [75]. The gene discussed is MAPT; the disease is Alzheimer disease.