To explore whether the CD146-HIF1-α axis was involved in the pathogenesis of BPD, we measured the expression of CD146 and HIF-1α in pulmonary tissues using PCR and Western blot, and both HIF-1α and CD146 were significantly higher in the BPD group than in the control group (Fig. 5H–J). This evidence concerns the gene HIF1A and bronchopulmonary dysplasia.