To determine the role of PKLR in PCa progression, we used a tissue microarray (TMA) obtained from the Department of Pathology at Duke University School of Medicine (Durham, NC, USA), which is composed of normal tissues (n = 16), adenocarcinomas with a Gleason score of ≤7 (n = 81), adenocarcinomas with a Gleason score of ≥8 (n = 19), and SCPC specimens (n = 8) to determine PKLR expression in different grades of PCa. Here, PKLR is linked to posterior cortical atrophy.