We found that the AR-negative PC3 [20] and NE-like NCI-H660 [7] and LASCPC01 [21] cell lines expressed higher PKLR and NE markers and lower androgen-responsive markers than did the AR-positive VCaP, LNCaP, and C4-2 prostate adenocarcinoma cell lines (Fig. 1H). The gene discussed is PKLR; the disease is prostate adenocarcinoma.