We focused on AR signaling components that were negatively correlated with PKLR according to GSEA negative rank metric scores in both PCa datasets with PKLR upregulation, and a Venn diagram showed that MAF, ACSL3, APPBP2, PIAS1, and ZBTB10 genes overlapped among three androgen-responsiveness signatures (Supplementary Fig. S2C, D). This evidence concerns the gene APPBP2 and posterior cortical atrophy.