In addition, we found that cells overexpressing ZBTB10 had lower OCR values, whereas ZBTB10-expressing cells rescued with PKLR had higher OCR values (Fig. 4N and Supplementary Fig. S6D), suggesting a role of PKLR involved in activating oxidative phosphorylation (OXPHOS) in PCa cells. Here, PKLR is linked to posterior cortical atrophy.