DLG4 and Alzheimer disease: In 6-month-old 3xTg-AD mice, we observed a significant increase in NR2B subunit (Fig. 2A, B; 1.28 ± 0.29 vs. 0.52 ± 0.07 arbitrary units, a.u.), PSD-95 (Fig. 2A, C; 5.83 ± 2.81 vs. 2.39 ± 0.29 a.u), synaptophysin (Fig. 2A, D, 4.83 ± 0.73 vs. 2.72 ± 0.62 a.u) and Aβ42 levels (Fig. 2E; 3.35 ± 0.86 vs. 0.66 ± 0.07 a.u) as compared to control animals (n = 5 mice in all instances).