Although deletion of AQP-4 in AQP-4 null mice as well as small molecule inhibitors of AQP-4 can improve neurological function after cytotoxic cellular edema from pathologies such as ischemic stroke or bacterial meningitis,39 worse outcomes are observed in vasogenic models of edema, such as brain tumors.40 The gene discussed is AQP4; the disease is brain neoplasm.