However, PDCD4 down-regulation following sIgM stimulation in CLL cells was not due to transcriptional regulation as Q-PCR analysis confirmed our previous finding, based on publicly available gene expression data [23], that down-regulation of PDCD4 protein by anti-IgM was not associated with a parallel reduction in PDCD4 mRNA (Fig. 2C). Here, PDCD4 is linked to B-cell chronic lymphocytic leukemia.