BCR and diffuse large B-cell lymphoma: In DLBCL cell lines, cell survival signaling can be driven by engagement of the BCR by self-antigen (i.e., antigen expressed by the lymphoma cells) or by a low-level, antigen-independent signal emanating from the BCR [29], [30], [31] similar to antigen-independent “tonic” signaling originally described in normal B cells [32], [33].