Constitutive BCR signaling has been described in various DLBCL cell lines, including HBL-1 cells analyzed here, and appears to be driven by engagement of the BCR by self-antigens expressed by the lymphoma cells or is a low-level, antigen-independent signal [29], [30], [31], [32], [33]. The gene discussed is BCR; the disease is diffuse large B-cell lymphoma.