A single study was performed so far in SCA3/MJD models, where the authors correlated the neurochemical biomarkers in homozygous YACMJD84.2 (Q84/Q84) and hemizygous CMVMJD135 (Q135) mice with the levels of Neurofilaments (NFL) and MBP measured in cerebellar lysates from a subset of mice and patients with SCA3 [24]. Here, NEFL is linked to Machado-Joseph disease.