ITGB4 and nonpapillary renal cell carcinoma: Results of transwell assay showed that ccRCC cell migration was considerably impaired by ITGB4 stable knockdown accompanied with attenuated cell invasiveness; on the other hand, the intensification of these cell phenotypes in vitro resulted from the lack of METTL14 could be significantly recovered by inhibiting ITGB4 expression (Fig. 8c, d).