In the process of exploring the mechanisms resulting in ITGB4’s abnormal expression in this malignancy, we were inspired by recent articles that have claimed a phenomenal role of METTL14 in controlling ccRCC metastasis via m6A modification on BPTF and P2RX6 [28, 29]. The gene discussed is METTL14; the disease is nonpapillary renal cell carcinoma.