Additionally, mature DC cells and CD8+ T cells were confirmed significantly higher in NPs + Laser group compared with the other control groups through quantitative analysis of CD8+ T cells in spleen and mature DC cells in tumor draining lymph nodes among four groups (Fig. 7g–j), which indicated that the synergistic phototherapy enabled by A1 NPs could induce antitumor T-cell immune responses. Here, CD8A is linked to neoplasm.