In addition, we constructed an in vivo model of xenografts in nude mice and confirmed that the shSLC4A4 group had a significant inhibitory effect on PCa tumour growth in vivo compared to the shCtrl group, which was also supported by the relatively lower bioluminescence intensity levels and Ki-67 expression in the tumours of the shSLC4A4 group. Here, MKI67 is linked to posterior cortical atrophy.