Similar to the above results, flow cytometry analysis confirmed that ERK inhibition enhanced apoptosis of HuCCT1 (Fig. 4D, E) and RBE (Fig. 4F, G) cells, while autophagy defects in both of them significantly reduced the percentage of apoptotic tumor cells when co-cultured with activated CD8+T lymphocytes. Here, CD8A is linked to neoplasm.