ACE and Behcet disease: Although the ACE I/D polymorphism did not seem to play a role in etiopathogenesis of BD in the two smaller studies (N = 90 BD and N = 30 healthy controls, N = 73 BD and N = 90 controls) by Ozturk et al. [31] and Dursun et al. [30], Turgut and colleagues [10] found a statistically significant association of the ACE I/D polymorphism with BD in 35 patients and 150 healthy individuals.