In recently years, Wang YM and Hao XD et al. both analyzed the association of SNP locus with keratoconus in Chinese population, and revealed that the rs1324183 (MPDZ-NF1B), which located between the MPDZ and NF1B genes, is a putative genetic marker for monitoring the progression of keratoconus and should be further investigated in other different Chinese populations [23, 24]. This evidence concerns the gene NFIB and keratoconus.