The updated results also suggested that this agent is the first second-generation EGFR-TKI that was demonstrated to improve overall survival (OS) in advanced NSCLC with 19del or 21 L858R (34.1 months vs. 26.8 months, HR = 0.76, 95% CI, 0.58–0.99, P = 0.044) [14]. This evidence concerns the gene EGFR and non-small cell lung carcinoma.