Zhang, et al. analyzed the expression of MAD2L1 in hepatocellular carcinoma and its clinicopathological significance and found that MAD2L1 was frequently overexpressed in hepatocellular carcinoma, including abnormal hepatocellular nodules and early lobular hepatocellular carcinoma, indicating that the overexpression of MAD2L1 plays a certain role in the occurrence and development of hepatocellular carcinoma. Here, MAD2L1 is linked to hepatocellular carcinoma.