Through prognostic analysis of PCa patients in TCGA, it was found that the MAD2L1 gene can be used to predict the prognosis of patients, especially after years of illness, the prognosis of patients with high expression of the MAD2L1 gene is significantly worse, indicating that if the MAD2L1 gene can be down-regulated to prevent tumor cells from proliferating in large numbers, it may help the prognosis of patient. Here, MAD2L1 is linked to posterior cortical atrophy.